The former Dancing With The Stars contestant was spotted quarrelling with his rumoured girlfriend - British model and singer Rita Ora - shortly before the drama unfolded.
After apparently realising he was being photographed, the 25-year-old reality star ran after the paparazzo and cornered him in a tobacco store.
In cuffs: Rob Kardashian is handcuffed by police in Miami in the early hours of Sunday morning after giving chase to a photographer
But a pair of police officers quickly restrained Rob and put him in cuffs.
In a video posted on TMZ, the photographer can be heard saying: 'He's attacking me ... he chased me ... he tried to kill me.' Rob is not seen making contact with the photographer during the video clip.
Altercation: The reality star was seen quarrelling with his rumoured girlfriend Rita Ora shortly before the drama
Asked what he was doing there, Rob told the officers he was 'shopping'.
The incident happened in the early hours of Sunday morning. Rob was detained in a police car for around an hour before being released without charge.
According to a police report obtained by TMZ, Rob told police he gave chase because he 'did not like the paparazzi filming him'.
After interviewing both Rob and the photographer, Police decided to take no action.
New couple alert? Rob and Rita were spotted leaving a club separately last month in London